Prediction of genome-wide DNA methylation for the repetitive facets

Prediction of genome-wide DNA methylation for the repetitive facets

Yinan Zheng, Brian T. Joyce, Lei Liu, Zhou Zhang, Warren A good. Kibbe, Wei Zhang, Lifang Hou, Anticipate regarding genome-large DNA methylation within the repeated issue, Nucleic Acids Look, Frequency forty-five, Point fifteen, , Pages 8697–8711,

Abstract

DNA methylation in the repetitive facets (RE) prevents their mobility and you will retains genomic balances, and you can minimizes inside are often present in tumefaction and you will/otherwise surrogate structures. Averaging methylation round the Re also from inside the genome is actually widely used to help you assess all over the world methylation. However, methylation may vary in certain Re and you may enjoy varied roles within the problem development, ergo averaging methylation round the Re also biguous mapping out-of short checks out because of the and you may high price of latest bisulfite sequencing networks make certain they are unlikely to possess quantifying locus-certain Re methylation. Regardless of if microarray-built means (such as for instance Illumina’s Infinium methylation arrays) promote prices-productive and you will sturdy genome-greater methylation measurement, the amount of interrogated CpGs for the Re stays minimal. (más…)